Candy Caries revolves around Ame, a young girl with a sweet tooth, and her unlikely companion Caries, a mischievous cavity living inside her mouth. Caries refers to Ame as "Mama" and wields control over her body and teeth, frequently causing chaos in their daily lives. As a result, Ame's interactions are often dictated by Caries' unpredictable behavior. This unusual pair's antics are the focal point of the show's slapstick comedy.