Gangsta's storyline revolves around Worick Arcangelo and Nicolas Brown, two "Handymen" who operate in a world where people with supernatural abilities, known as "Wolpe Bretas," live in secret. As they navigate their work and personal relationships, they become entangled in a complex web of intrigue with the city's powerful forces. The series explores the darker aspects of their world through the characters' struggles with crime, corruption, and their own troubled pasts.